کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8298900 | 1537049 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondrial uncoupling proteins in unicellular eukaryotes
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کلمات کلیدی
QH2Coenzyme Q, UbiquinoneUCPHNEFCCPAOXFFA4-hydroxy-2-nonenal - 4-هیدروکسی-2 غیرنالROS - ROSΔμH+ - ΔHH +Δψ - ΔρEnergy dissipation - اتلاف انرژیFree fatty acid - اسید چرب آزادAlternative oxidase - اکسیداز جایگزینUncoupling proteins - جدا کردن پروتئین هاelectrochemical proton gradient - شیب پروتون الکتروشیمیاییFungi - قارچMitochondria - میتوکندریاPurine nucleotide - نوکلئوتید پورینUncoupling protein - پروتئین جدا کردنReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mitochondrial uncoupling proteins in unicellular eukaryotes Mitochondrial uncoupling proteins in unicellular eukaryotes](/preview/png/8298900.png)
چکیده انگلیسی
Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier protein family that are present in the mitochondrial inner membrane and mediate free fatty acid (FFA)-activated, purine nucleotide (PN)-inhibited proton conductance. Since 1999, the presence of UCPs has been demonstrated in some non-photosynthesising unicellular eukaryotes, including amoeboid and parasite protists, as well as in non-fermentative yeast and filamentous fungi. In the mitochondria of these organisms, UCP activity is revealed upon FFA-induced, PN-inhibited stimulation of resting respiration and a decrease in membrane potential, which are accompanied by a decrease in membranous ubiquinone (Q) reduction level. UCPs in unicellular eukaryotes are able to divert energy from oxidative phosphorylation and thus compete for a proton electrochemical gradient with ATP synthase. Our recent work indicates that membranous Q is a metabolic sensor that might utilise its redox state to release the PN inhibition of UCP-mediated mitochondrial uncoupling under conditions of phosphorylation and resting respiration. The action of reduced Q (QH2) could allow higher or complete activation of UCP. As this regulatory feature was demonstrated for microorganism UCPs (A. castellanii UCP), plant and mammalian UCP1 analogues, and UCP1 in brown adipose tissue, the process could involve all UCPs. Here, we discuss the functional connection and physiological role of UCP and alternative oxidase, two main energy-dissipating systems in the plant-type mitochondrial respiratory chain of unicellular eukaryotes, including the control of cellular energy balance as well as preventive action against the production of reactive oxygen species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1797, Issues 6â7, JuneâJuly 2010, Pages 792-799
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics - Volume 1797, Issues 6â7, JuneâJuly 2010, Pages 792-799
نویسندگان
Wieslawa Jarmuszkiewicz, Andrzej Woyda-Ploszczyca, Nina Antos-Krzeminska, Francis E. Sluse,