Hitting the brakes: Termination of mitochondrial transcription

► Termination of transcription in mitochondria is not well characterized. ► Human MTERF1 mediates termination at a major site in tRNALeu. ► MTERF1 utilizes a unique binding mechanism to promote termination. ► There are connections between transcription termination and mtDNA replication. ► Other MTERF family members have been implicated in termination and replication.