Entamoeba histolytica thioredoxin reductase: Molecular and functional characterization of its atypical properties

► The amoebic enzyme can use NADPH or NADH as substrates in μM concentrations. ► EhTRXR catalyzes the thioredoxin-independent reduction of S‐nitrosothiols. ► EhTRXR can use non-physiological substrates with similar catalytic efficiency.