The ins and outs of phosphatidylethanolamine synthesis in Trypanosoma brucei

► The substrates and pathways for PE synthesis differ considerably among organisms. ► PE is not only a membrane component but also a substrate for many cellular events. ► T. brucei is a valuable model eukaryote to study the many roles of PE. ► Depletion of PE in T. brucei results in morphological changes and parasite death