Drug induced phospholipidosis: An acquired lysosomal storage disorder

► Lysosomal storage diseases may be either inherited or acquired. ► Drug induced phospholipidosis is a form of acquired lysosomal storage disease. ► The mechanism for and pathological significance of phospholipidosis is not well understood. ► LPLA2 is a recently characterized lysosomal hydrolase. ► LPLA2 is a target for amiodarone induced phospholipidosis.