Physiological roles of phosphatidylethanolamine N-methyltransferase

► Lack of PEMT protects against atherosclerosis and lipotoxic cardiac dysfunction. ► Lack of PEMT protects against obesity and insulin resistance. ► The PEMT reaction is important for formation of choline and homocysteine. ► Lack of PEMT and dietary choline results in liver failure in 3 days.