Insight into NSAID-induced membrane alterations, pathogenesis and therapeutics: Characterization of interaction of NSAIDs with phosphatidylcholine

► NSAIDs attenuate GI barrier properties by associating with phospholipids. ► NSAID interaction with membrane phospholipids alters cell function. ► NSAIDs affect cell signaling by changing the membrane micro-environment. ► Reduction of GI injury by association of NSAIDs with phosphatidylcholine