کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8304627 | 1538412 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-κB in human monocytic cells
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کلمات کلیدی
NF-κBIL-1ERKPKCPMA - LDC هاinterleukin-1 - اینترلوکین-1THP-1 cells - سلول های THP-1Pro-inflammatory cytokines - سیتوکینهای پروتئین التهابیAnti-inflammation - ضد التهابnuclear factor-κB - فاکتور هسته ای κBProtein kinase C - پروتئین کیناز سیExtracellular signal-regulated protein kinase - پروتئین کیناز کنترل شده سیگنال غیر سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The compound 6-O-veratroyl catalpol (6-O) is a bioactive iridoid glucoside that was originally isolated from Pseudolysimachion rotundum var. subintegrum. It has been demonstrated that catapol derivative iridoid glucosides including 6-O, possess anti-inflammatory activity in carragenan-induced paw edema mouse model as well as bronchoalveolar lavage fluid of ovalbumin-induced mouse model. In the present study, we investigated whether 6-O modulates inflammatory responses in THP-1 monocytic cells stimulated with phorbol12-myristate-13-acetate (PMA). Our data showed that 6-O inhibited PMA induced interleukin (IL)-1β and tumor necrosis factor (TNF)-α expression in THP-1 monocytic cells. Mechanistic studies revealed that 6-O suppressed the activity of protein kinase C (PKC), which further resulted in downstream inactivation of extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB) inflammatory pathway. The results implied that 6-O may protect against inflammatory responses that could be a potential compound in treating inflammatory diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 119, December 2015, Pages 52-59
Journal: Biochimie - Volume 119, December 2015, Pages 52-59
نویسندگان
Minh Quan Le, Man Sub Kim, Yong-Seok Song, Hyung Won Ryu, Sei-Ryang Oh, Do-Young Yoon,