Development and clinical application of a LC-MS/MS method for simultaneous determination of various tyrosine kinase inhibitors in human plasma

► Specific, simple and rapid quantification method for tyrosine kinase inhibitors in human plasma. ► Simultaneous determination of erlotinib, imatinib, lapatinib, nilotinib, sorafenib, sunitinib. ► Clinical applications for TKI measurement during anticancer therapy.