N-terminal domains of human DNA polymerase lambda promote primer realignment during translesion DNA synthesis

- The Polλ BRCT domain increases the efficiency of abasic site bypass.
- The Polλ proline-rich domain stimulates generation of −2 frameshift mutations.
- The Polλ BRCT domain represses spontaneous generation of −2 frameshift mutations.
- The N-terminal domains of Polλ cooperatively promote looping out of damaged bases.