FZD1 activates protein kinase C delta-mediated drug-resistance in multidrug-resistant MES-SA/Dx5 cancer cells

- FZD1 regulated PKCδ and its signalling transduction pathway in MDR cancer cells.
- Rottlerin reduced ABCB1 expression and inhibited the MDR drug pumping ability.
- The FZD1 shRNA-knockdown MDR cells reduced viability and drug pump-out ability.
- FZD1 inhibitor curcumin-treated MDR cells significantly reduced cell viability.