کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8323655 | 1539894 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells
ترجمه فارسی عنوان
انتگرال بتا-1 برای نگهداری ساختاری و هوموستاز سلول های فیبری متمایز مهم است
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کلمات کلیدی
ECMLECsconnexinsGMFcKOGDFF-actinIGFLFCSfilamentous actin - actin filamentousβ1-Integrin - β1-انتگرینILK - اولDifferentiation - تفکیکESC - خروجlens epithelial cells - سلول های اپیتلیال لنزlens fiber cells - سلول های فیبر لنزEmbryonic stem cells - سلولهای بنیادی جنینیSIM - سیم کارتconditional knockout - شکستن شرطLens - عدسی یا لنز Insulin-like growth factor - فاکتور رشد مانند انسولینExtracellular matrix - ماتریکس خارج سلولیStructured illumination microscopy - میکروسکوپ نورانی ساخت یافتهMembrane conductance - هدایت غشاءintegrin linked kinase - پیوند کیناز انتگرالCytoskeleton - چارچوب یاخته، سیتواسکلتون، اسکلت سلولیconnexin - کنسکسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
β1-Integrin is a heterodimeric transmembrane protein that has roles in both cell-extra-cellular matrix and cell-cell interactions. Conditional deletion of β1-integrin from all lens cells during embryonic development results in profound lens defects, however, it is less clear whether this reflects functions in the lens epithelium alone or whether this protein plays a role in lens fibers. Thus, a conditional approach was used to delete β1-integrin solely from the lens fiber cells. This deletion resulted in two distinct phenotypes with some lenses exhibiting cataracts while others were clear, albeit with refractive defects. Analysis of “clear” conditional knockout lenses revealed that they had profound defects in fiber cell morphology associated with the loss of the F-actin network. Physiological measurements found that the lens fiber cells had a twofold increase in gap junctional coupling, perhaps due to differential localization of connexins 46 and 50, as well as increased water permeability. This would presumably facilitate transport of ions and nutrients through the lens, and may partially explain how lenses with profound structural abnormalities can maintain transparency. In summary, β1-integrin plays a role in maintaining the cellular morphology and homeostasis of the lens fiber cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 50, May 2014, Pages 132-145
Journal: The International Journal of Biochemistry & Cell Biology - Volume 50, May 2014, Pages 132-145
نویسندگان
David A. Scheiblin, Junyuan Gao, Jeffrey L. Caplan, Vladimir N. Simirskii, Kirk J. Czymmek, Richard T. Mathias, Melinda K. Duncan,