کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8324531 1539912 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MiRNA expression analysis of cancer-associated fibroblasts and normal fibroblasts in breast cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
MiRNA expression analysis of cancer-associated fibroblasts and normal fibroblasts in breast cancer
چکیده انگلیسی
► MiRNAs expression profile of cancer-associated fibroblasts and normal fibroblasts derived from breast cancer tissue and its paired normal tissue was systemically analyzed by using miRNA-microarray. ► Three up-regulated miRNAs were found in CAFs: miR-221-5p, miR-31-3p, miR-221-3p. Eight miRNAs were down-regulated in CAFs: miR-205, miR-200b, miR-200c, miR-141, miR-101, miR-342-3p, let-7g, miR-26b. ► The predicted target genes of disregulated miRNAs are involved in a variety of signaling pathways, such as IL-6 and TGF-β pathways, associated with differentiation and function of CAF. ► The activation of IL-6 and TGF-β signaling pathways were proved to play a role in cell migration of CAFs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 44, Issue 11, November 2012, Pages 2051-2059
نویسندگان
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