کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8325452 | 1539937 | 2010 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes
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کلمات کلیدی
ICDH1O2G6PHMPNOSLPOOXPHOSG6PDMitochondrial DNA - DNA میتوکندریاH2O - H2OO2− - O2-ONOO− - ONOO-ROS - ROSWater - آبHydrogen peroxide - آب اکسیژنهAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPsuperoxide anion - آنیون سوپر اکسیدROH - ابدیPolyunsaturated fatty acids - اسید چرب اشباع نشدهPUFA - اسید چرب چند غیراشباعSinglet oxygen - اکسیژن مجزاMolecular oxygen - اکسیژن مولکولیIsocitrate dehydrogenase - ایزوسیترات دهیدروژنازmtDNA - دیانای میتوکندریاییHydroxyl radical - رادیکال هیدروکسیلROOH - روحcopper–zinc superoxide dismutase - سوپر اکسید دیسموتاز مس-رویOxidative phosphorylation - فسفوریلاسیون اکسیداتیوNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازH2O2 - هیدروژن پراکسیدPeroxy radical - پراکسی رادیکالLipid peroxides - پراکسید لیپیدPeroxynitrite - پروکسی نیتریتglucose-6-phosphate - گلوکز 6-فسفاتglucose-6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژنازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Reactive oxygen species (ROS) are generated as by-products of aerobic respiration and metabolism. Mammalian cells have evolved a variety of enzymatic mechanisms to control ROS production, one of the central elements in signal transduction pathways involved in cell proliferation, differentiation and apoptosis. Antioxidants also ensure defenses against ROS-induced damage to lipids, proteins and DNA. ROS and antioxidants have been implicated in the regulation of reproductive processes in both animal and human, such as cyclic luteal and endometrial changes, follicular development, ovulation, fertilization, embryogenesis, embryonic implantation, and placental differentiation and growth. In contrast, imbalances between ROS production and antioxidant systems induce oxidative stress that negatively impacts reproductive processes. High levels of ROS during embryonic, fetal and placental development are a feature of pregnancy. Consequently, oxidative stress has emerged as a likely promoter of several pregnancy-related disorders, such as spontaneous abortions, embryopathies, preeclampsia, fetal growth restriction, preterm labor and low birth weight. Nutritional and environmental factors may contribute to such adverse pregnancy outcomes and increase the susceptibility of offspring to disease. This occurs, at least in part, via impairment of the antioxidant defense systems and enhancement of ROS generation which alters cellular signalling and/or damage cellular macromolecules. The links between oxidative stress, the female reproductive system and development of adverse pregnancy outcomes, constitute important issues in human and animal reproductive medicine. This review summarizes the role of ROS in female reproductive processes and the state of knowledge on the association between ROS, oxidative stress, antioxidants and pregnancy outcomes in different mammalian species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 42, Issue 10, October 2010, Pages 1634-1650
Journal: The International Journal of Biochemistry & Cell Biology - Volume 42, Issue 10, October 2010, Pages 1634-1650
نویسندگان
Kaïs H. Al-Gubory, Paul A. Fowler, Catherine Garrel,