کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8329744 | 1540228 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RG-I regions from elderflower pectins substituted on GalA are strong immunomodulators
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کلمات کلیدی
rhamnogalacturonan type IXylogalacturonan3-Deoxy-d-manno-2-octulosonic acidMacrophage stimulationSambucus nigraRG-IIRG-IGlcXylRHAGlcAarabinogalactan type IIAG-IILPSKDO - WHOGalacturonic acid - اسید گالاکاتورونیکGlucuronic acid - اسید گلوکورونیکComplement system - دستگاه کمپلمان، سیستم کمپلمانrhamnose - رامنوزImmunological activity - فعالیت ایمنیlipopolysaccharide - لیپوپلی ساکاریدMannose - مانوزMan - مردMolecular weight - وزن مولکولیPectic polysaccharides - پلی ساکارید پکتGal - گالGalA - گالاGalactose - گالاکتوزمی Xylose - گزیلوزGlucose - گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sambuci flos, also known as elderflower, has traditionally been used and is still in use for treatment of various types of illnesses related to the immune system such as cold, flu, fever and inflammation. Pectic polysaccharides from 50% EtOH, 50 °C water and 100 °C water extracts from elderflowers were treated with endo-α-d-(1-4)-polygalacturonase after previous de-esterification with the intention of isolating hairy regions and relate variation in structure to immunomodulating activity. High molecular weight sub-fractions (25-29 kDa) and medium molecular weight sub-fractions (6-17 kDa) were isolated after enzymatic treatment in addition to oligogalacturonides. Structural elucidation indicated that RG-I regions with AG-I and AG-II sidechains were the predominant structures in the high molecular weight sub-fractions, and two of three 1,4-linked GalA units in the rhamnogalacturonan backbone were branched in either position 2 or 3. The medium molecular weight sub-fractions had monomers and linkages typical for both RG-I and RG-II. The results showed that the high molecular RG-I containing polymers exhibit the highest dose-dependent complement fixing and macrophage stimulating activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 92, November 2016, Pages 731-738
Journal: International Journal of Biological Macromolecules - Volume 92, November 2016, Pages 731-738
نویسندگان
Giang Thanh Thi Ho, Yuan-Feng Zou, Helle Wangensteen, Hilde Barsett,