کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336168 | 1540435 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells
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کلمات کلیدی
PBSISGN-methyl-d-aspartateNMDALPOPALMEAStereology - استریولوژیSpermine - اسپرمimm - انحصارIschemia - ایسکمیcornu ammonis - بال آمونCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیSham - شامCoefficient of Variation - ضریب تغییرcoefficient of error - ضریب خطاphosphate buffered solution - محلول بافر فسفاتHippocampus - هیپوکامپ Learning - یادگیریpassive avoidance learning - یادگیری اجتناب ناپذیر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: Association with neuroprotection of pyramidal cells](/preview/png/8336168.png)
چکیده انگلیسی
The aim of this study is to investigate the effects of spermine and the passive avoidance learning on hippocampus following transient cerebral ischemia in the chicks. The study is composed of the pure control (CG), sham (SG) and experimental groups (n = 20). Experimental groups (ischemia group, IG and ischemia-spermine group, ISG) were exposed to ischemia for 20 min whereas the SG was exposed to sham operation and CG group was not exposed to any operation. Passive avoidance learning (PAL) was applied to the half number of the subjects in each group. Both before and after 7 days from the ischemia, operated animals were taken to PAL and then they were sacrificed. Total numbers of neurons in the hippocampus were stereologically estimated using Cresyl violet stained sections. We detected that number of neurons was increased following PAL and especially spermine treatment. According to our results, we suggested that spermine may reduce the deleterious effects of the ischemia by causing to increase in the neuronal number and so, it may be slightly supportive to the PAL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volume 88, March 2018, Pages 41-45
Journal: Journal of Chemical Neuroanatomy - Volume 88, March 2018, Pages 41-45
نویسندگان
Suleyman Kaplan, M. Emin Onger, B. Zuhal Altunkaynak, Ebru Elibol, Omur G. Deniz, M. Ãnder KarayiÄit, Murat Yarım, Cafer Marangoz, Murat Ãetin Ragbetli,