کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336388 | 1540613 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1
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کلمات کلیدی
cyto cELOVL3TMEM26PRDM16CD137cell death-inducing DFFA-like effector aRERTbx1AMPKPGC-1αBATHFDRASGTTAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استUcp1 - UCP1epididymal white adipose tissue - بافت چربی سفید اپیدیدیمinguinal white adipose tissue - بافت چربی سفید گوشتیbrown adipose tissue - بافت چربی قهوه ایBrowning - براونینگThermogenesis - ترموژنزglucose tolerance test - تست تحمل گلوکزRaspberry - تمشکhigh-fat diet - رژیم غذایی با چربی بالاcytochrome c - سیتوکروم سیObesity - مرض چاقیRespiratory exchange ratio - نسبت تبادل تنفسیuncoupling protein 1 - پروتئین جدا سازی 1transmembrane protein 26 - پروتئین غشایی 26Cidea - کید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1 Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1](/preview/png/8336388.png)
چکیده انگلیسی
Development of brown and beige/brite adipocytes increases thermogenesis and helps to reduce obesity and metabolic syndrome. Our previous study suggests that dietary raspberry can ameliorate metabolic syndromes in diet-induced obese mice. Here, we further evaluated the effects of raspberry on energy expenditure and adaptive thermogenesis and determined whether these effects were mediated by AMP-activated protein kinase (AMPK). Mice deficient in the catalytic subunit of AMPKα1 and wild-type (WT) mice were fed a high-fat diet (HFD) or HFD supplemented with 5% raspberry (RAS) for 10 weeks. The thermogenic program and related regulatory factors in adipose tissue were assessed. RAS improved the insulin sensitivity and reduced fat mass in WT mice but not in AMPKα1-/- mice. In the absence of AMPKα1, RAS failed to increase oxygen consumption and heat production. Consistent with this, the thermogenic gene expression in brown adipose tissue and brown-like adipocyte formation in subcutaneous adipose tissue were not induced by RAS in AMPKα1-/- mice. In conclusion, AMPKα1 is indispensable for the effects of RAS on brown and beige/brite adipocyte development, and prevention of obesity and metabolic dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 55, May 2018, Pages 157-164
Journal: The Journal of Nutritional Biochemistry - Volume 55, May 2018, Pages 157-164
نویسندگان
Tiande Zou, Bo Wang, Qiyuan Yang, Jeanene M. de Avila, Mei-Jun Zhu, Jinming You, Daiwen Chen, Min Du,