کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8337294 | 1540670 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice
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کلمات کلیدی
MnSODsE-selectinLOX-1oxLDLE3LCXCL1PON1MCP-1WTDRT-PCRLPSSMCCETP3-hydroxy-3-methylglutaryl coenzyme A reductase - 3-هیدروکسی-3-متیل گلوتاریل کوآنزیم A ردوکتاز8-iso-PGF2α - 8-ISO-PGF2αsoluble E-selectin - E-selectin قابل حل استHMG-CoA reductase - HMG-CoA ردوکتازOxidized LDL - LDL اکسید شدهAtherosclerosis - آترواسکلروز(تصلب شریان)Statin - استاتینinflammation - التهاب( توروم) immunoglobulin - ایمونوگلوبولینinterleukin - اینترلوکینTriglycerides - تریگلیسریدOxidative stress - تنش اکسیداتیوResveratrol - رسوراترولWestern-type diet - رژیم غذایی غربیSmooth muscle cell - سلول عضلانی صافmanganese superoxide dismutase - سوپر اکسید دیسموتاز منگنزlipopolysaccharide - لیپوپلی ساکاریدreal-time polymerase chain reaction - واکنش زنجیره ای پلیمراز واقعی در زمان واقعیParaoxonase-1 - پاراکسوناز-1monocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1Lipids - چربیهاLectin-like oxidized low-density lipoprotein receptor-1 - گیرنده لپسی پروتئین با چگالی کم اکسید شده توسط لکتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Resveratrol is a major constituent of traditional Asian medicinal herbs and red wine and is suggested to be a potential antiatherosclerotic drug due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study was to evaluate whether resveratrol protects against atherosclerosis development in APOE*3-Leiden.CETP (E3L.CETP) mice and adds to the antiatherogenic effect of mild statin treatment, currently the most widely used antiatherogenic therapy. E3L.CETP mice were fed a cholesterol-rich diet without (control) or with resveratrol (0.01% w/w), atorvastatin (0.0027% w/w) or both for 14 weeks. During the study plasma lipid, inflammatory and oxidative stress parameters were determined. Resveratrol reduced atherosclerotic lesion area (â52%) in the aortic root, comparable to atorvastatin (â40%) and the combination of both drugs (â47%). The collagen/macrophage ratio in the atherosclerotic lesion, a marker of plaque stability, was increased by resveratrol (+108%), atorvastatin (+124%) and the combination (+154%). Resveratrol decreased plasma cholesterol levels (â19%) comparable to atorvastatin (â19%) and the combination (â22%), which was completely confined to (very)low-density lipoprotein cholesterol levels in all groups. Post hoc analyses showed that the antiatherogenic effect of atorvastatin could be explained by cholesterol lowering, while the antiatherosclerotic effect of resveratrol could be attributed to factors additional to cholesterol lowering. Markers of inflammation and oxidative stress were not different, but resveratrol improved macrophage function. We conclude that resveratrol potently reduces atherosclerosis development and induces a more stable lesion phenotype in E3L.CETP mice. However, under the experimental conditions tested, resveratrol does not add to the antiatherogenic effect of atorvastatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 8, August 2013, Pages 1423-1430
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 8, August 2013, Pages 1423-1430
نویسندگان
Jimmy F.P. Berbée, Man C. Wong, Yanan Wang, José W.A. van der Hoorn, Padmini P.S.J. Khedoe, Jan B. van Klinken, Isabel M. Mol, Pieter S. Hiemstra, Dimitrios Tsikas, Johannes A. Romijn, Louis M. Havekes, Hans M.G. Princen, Patrick C.N. Rensen,