کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8338370 | 1541005 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3
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کلمات کلیدی
LBMSREBPVDRUCP25-hydroxycholecalciferolCaSRRIAFFMSRCTOBEC1,25(OH)2D3 - 1،25 (OH) 2D31,25-dihydroxyvitamin D - 1،25-دی هیدروکسوییتامین DWhite adipose tissue - بافت چربی سفیدLean body mass - توده بدون چربی بدنUncoupling proteins - جدا کردن پروتئین هاFat Free Mass - جرم آزاد چربیradioimmunoassay - رادیوایمونواسیTAF - می دانمtotal body electrical conductivity - هدایت الکتریکی بدنVitamin D - ویتامین دیsterol regulatory element binding protein - پروتئین اتصال دهنده عصاره استرولUncoupling protein - پروتئین جدا کردنadiposity - چاقیWAT - چیCalcium - کلسیمsteroid receptor coactivator - گیرنده استروئید گیرندهCalcium-sensing receptor - گیرنده سنجش کلسیمVitamin D receptor - گیرنده ویتامین D
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3 Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3](/preview/png/8338370.png)
چکیده انگلیسی
The vitamin D endocrine system is functional in the adipose tissue, as demonstrated in vitro, in cultured adipocytes, and in vivo in mutant mice that developed altered lipid metabolism and fat storage in the absence of either 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] or the vitamin D receptor. The aim of the present study was to examine the role of vitamin D and calcium on body adiposity in a diet-induced vitamin D deficient rat model. Vitamin D-deficient rats gained less weight and had lower amounts of visceral fat. Consistent with reduced adipose tissue mass, the vitamin D-deficient rats had low circulating levels of leptin, which reflects body fat stores. Expression of vitamin D and calcium sensing receptors, and that of genes involved in adipogenesis such as peroxisome proliferator-activated receptor, fatty acid synthase and leptin were significantly reduced in white adipose tissue of deficient rats compared to vitamin D-sufficient rats. Furthermore, the expression of uncoupling proteins (Ucp1 and Ucp2) was elevated in the white adipose tissue of the deficient rat indicative of higher energy expenditure, thereby leading to a lean phenotype. Expression of the p160 steroid receptor coactivator3 (SRC3), a key regulator of adipogenesis in white adipose tissue was decreased in vitamin D-deficient state. Interestingly, most of the changes observed in vitamin D deficient rats were corrected by calcium supplementation alone. Our data demonstrates that dietary vitamin D and calcium regulate adipose tissue function and metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 144, Part B, October 2014, Pages 304-312
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 144, Part B, October 2014, Pages 304-312
نویسندگان
Mehrajuddin Bhat, Bindu Noolu, Syed SYH Qadri, Ayesha Ismail,