کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8338430 | 1541005 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Environmental and genetic determinants of vitamin D insufficiency in 12-month-old infants
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PPF25(OH)D225-Hydroxyvitamin D2VDICYP2R1CYP27B1FLGVDRUVRCYP24A1SNPs24-hydroxylase - 24 هیدروکسیلاز25(OH)D3 - 25 (OH) D325-hydroxyvitamin D3 - 25 هیدروکسی ویتامین D325-hydroxylase - 25 هیدروکسیلازLC-MS/MS - LC-MS / MSUltraviolet radiation - اشعه ماوراء بنفشInfant formula - شیر خشکBreastfeeding - شیردهی یا تغذیه با شیر مادر Liquid chromatography-tandem mass spectrometry - طیف سنجی جرمی کروماتوگرافی مایع دو طرفهLinkage disequilibrium - عدم تعادل پیوستگیfilaggrin - فیلهگرینGenetic association studies - مطالعات مرتبط با ژنتیکCohort studies - مطالعه کوهورت odds ratio - نسبت شانس هاVitamin D - ویتامین دیVitamin D binding protein - پروتئین متصل به ویتامین DSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدVitamin D receptor - گیرنده ویتامین D
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We aimed to investigate the relationship between genetic and environmental exposure and vitamin D status at age one, stratified by ethnicity. This study included 563 12-month-old infants in the HealthNuts population-based study. DNA from participants' blood samples was genotyped using Sequenom MassARRAY MALDI-TOF system on 28 single nucleotide polymorphisms (SNPs) in six genes. Using logistic regression, we examined associations between environmental exposure and SNPs in vitamin D pathway and filaggrin genes and vitamin D insufficiency (VDI). VDI, defined as serum 25-hydroxyvitamin D3(25(OH)D3) level â¤50 nmol/L, was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Infants were stratified by ethnicity determined by parent's country of birth. Infants formula fed at 12 months were associated with reduced odds of VDI compared to infants with no current formula use at 12 months. This association differed by ethnicity (Pinteraction = 0.01). The odds ratio (OR) of VDI was 0.29 for Caucasian infants (95% CI, 0.18-0.47) and 0.04 for Asian infants (95% CI, 0.006-0.23). Maternal vitamin D supplementation during pregnancy and/or breastfeeding were associated with increased odds of infants being VDI (OR, 2.39; 95% CI, 1.11-5.18 and OR, 2.5; 95% CI, 1.20-5.24 respectively). Presence of a minor allele for any GC SNP (rs17467825, rs1155563, rs2282679, rs3755967, rs4588, rs7041) was associated with increased odds of VDI. Caucasian infants homozygous (AA) for rs4588 had an OR of 2.49 of being associated with VDI (95% CI, 1.19-5.18). In a country without routine infant vitamin D supplementation or food chain fortification, formula use is strongly associated with a reduced risk of VDI regardless of ethnicity. There was borderline significance for an association between filaggrin mutations and VDI. However, polymorphisms in vitamin D pathway related genes were associated with increased likelihood of being VDI in infancy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 144, Part B, October 2014, Pages 445-454
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 144, Part B, October 2014, Pages 445-454
نویسندگان
Noor H.A. Suaini, Jennifer J. Koplin, Justine A. Ellis, Rachel L. Peters, Anne-Louise Ponsonby, Shyamali C. Dharmage, Melanie C. Matheson, Melissa Wake, Mary Panjari, Hern-Tze Tina Tan, Pamela E. Martin, Angela Pezic, Adrian J. Lowe, David Martino,