Anti-apoptotic phenotypes of cholestan-3β,5α,6β-triol-resistant human cholangiocytes: Characteristics contributing to the genesis of cholangiocarcinoma

- We examine the mechanisms of oxysterol-induced apoptosis resistance.
- Long-term exposure to Triol causes apoptosis resistant cells.
- Kinase signaling cascade was activated in Triol-exposed cells.
- Increased expression of anti-apoptosis proteins was found in Triol-exposed cells.