1,25-Dihydroxyvitamin D3 modulates lipid metabolism in prostate cancer cells through miRNA mediated regulation of PPARA

▸ Vitamin D3 and androgen coordinately regulate the expression of miR-17/92 cluster. ▸ There are 9 potential miR-17/92 target sites in the PPARA 3′UTR. ▸ VDR and AR may regulate PPARA post-transcriptionally via miR-17/92 cluster. ▸ PPARA mediates vitamin D- and androgen-induced neutral lipid accumulation.