کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8341080 | 1541279 | 2016 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sublingual microvascular perfusion is altered during normobaric and hyperbaric hyperoxia
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کلمات کلیدی
AVIPaCO2PaO2FiO2HbOAVAPVDHBOTPPVTVDNormobaricDVIROIMSWMFISpO2perfused vessel densityEuropean Union - اتحادیه اروپاoxygen saturation - اشباع اکسیژنperipheral capillary oxygen saturation - اشباع اکسیژن مویرگی محیطیLCD - ال سی دیgauge - اندازه گیریOxygen - اکسیژنHyperbaric oxygen - اکسیژن بیش از حدhyperbaric oxygen therapy - اکسیژن درمان با فشار بالاDirect Current - جریان مستقیمbaseline - خط مقدمATM - خودپردازSO2 - دی اکسید گوگردDiameter - دیامتر یا قطر دایرهMicrocirculation - ریز جریانsubcutaneous - زیر جلدیred blood cell(s) - سلول های قرمز خون)liquid crystal display - صفحه نمایش کریستال مایعpartial pressure of oxygen in arterial blood - فشار جزئی اکسیژن در خون شریانیpartial pressure of carbon dioxide in arterial blood - فشار جزئی دی اکسید کربن در خون شریانیHyperbaric - فشارخون بالاOuter diameter - قطر خارجیinner diameter - قطر داخلیmucosa - مخاطAnimal model - مدل حیوانیregion of interest - منطقه مورد نظرHyperoxia - هیپوکسیاFraction of inspired oxygen - کسری از اکسیژن الهام گرفته
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hyperoxia and hyperbaric oxygen therapy can restore oxygen tensions in tissues distressed by ischemic injury and poor vascularization and is believed to also yield angiogenesis and regulate tissue perfusion. The aim of this study was to develop a model in which hyperoxia-driven microvascular changes could be quantified and to test the hypothesis that microcirculatory responses to both normobaric (NB) and hyperbaric (HB) hyperoxic maneuvers are reversible. Sublingual mucosa microcirculation vessel density, proportion of perfused vessels, vessel diameters, microvascular flow index, macrohemodynamic, and blood gas parameters were examined in male rabbits breathing sequential O2/air mixtures of 21%, 55%, 100%, and return to 21% during NB (1.0 bar) and HB (2.5 bar) conditions. The results indicate that NB hyperoxia (55% and 100%) produced significant decreases in microvascular density and vascular diameters (p < 0.01 and p < 0.05, respectively) accompanied by significant increases in systolic and mean arterial blood pressure (p < 0.05, respectively) with no changes in blood flow indices when compared to NB normoxia. HB normoxia/hyperoxia resulted in significant decreases in microvascular density (p < 0.05), a transient rise in systolic blood pressure at 55% (p < 0.01), and no changes in blood vessel diameter and blood flow indices when compared to NB hyperoxia. All microcirculation parameters reverted back to normal values upon return to NB normoxia. We conclude that NB/HB hyperoxia-driven changes elicit reversible physiological control of sublingual mucosa blood perfusion in the presence of steady cardiovascular function and that the absence of microvascular vasoconstriction during HB conditions suggests a beneficial mechanism associated with maintaining peak tissue perfusion states.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 105, May 2016, Pages 93-102
Journal: Microvascular Research - Volume 105, May 2016, Pages 93-102
نویسندگان
Dan M.J. Milstein, Renée Helmers, Sanne Hackmann, Charly N.W. Belterman, Robert A. van Hulst, Jan de Lange,