کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8341497 | 1541453 | 2013 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The ABCs of membrane transporters in health and disease (SLC series): Introduction
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کلمات کلیدی
SLCGLUT1SLC2A1CotransporterABC transporter - ABC حمل کنندهAntiporter - antiporteraquaporin - آکواپورینsolute transport - انتقال املاحDiabetes - بیماری قندPump - تلمبهCarrier - حاملCoupled transport - حمل و نقل همراهGlucose transporter - حمل و نقل گلوکزion transport - حمل و نقل یونTransporter - حمل کنندهStructure - ساختار یا سازهSymporter - سمپوزیومExchanger - مبدلUniporter - ناشرNomenclature - نامتقارنWater soluble vitamins - ویتامین های محلول در آبMembrane proteins - پروتئین غشاءChannel - کانال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The field of transport biology has steadily grown over the past decade and is now recognized as playing an important role in manifestation and treatment of disease. The SLC (solute carrier) gene series has grown to now include 52 families and 395 transporter genes in the human genome. A list of these genes can be found at the HUGO Gene Nomenclature Committee (HGNC) website (see www.genenames.org/genefamilies/SLC). This special issue features mini-reviews for each of these SLC families written by the experts in each field. The existing online resource for solute carriers, the Bioparadigms SLC Tables (www.bioparadigms.org), has been updated and significantly extended with additional information and cross-links to other relevant databases, and the nomenclature used in this database has been validated and approved by the HGNC. In addition, the Bioparadigms SLC Tables functionality has been improved to allow easier access by the scientific community. This introduction includes: an overview of all known SLC and “non-SLC” transporter genes; a list of transporters of water soluble vitamins; a summary of recent progress in the structure determination of transporters (including GLUT1/SLC2A1); roles of transporters in human diseases and roles in drug approval and pharmaceutical perspectives.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Aspects of Medicine - Volume 34, Issues 2â3, AprilâJune 2013, Pages 95-107
Journal: Molecular Aspects of Medicine - Volume 34, Issues 2â3, AprilâJune 2013, Pages 95-107
نویسندگان
Matthias A. Hediger, Benjamin Clémençon, Robert E. Burrier, Elspeth A. Bruford,