کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8351587 | 1541871 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidepressant-like activity of resveratrol treatment in the forced swim test and tail suspension test in mice: The HPA axis, BDNF expression and phosphorylation of ERK
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کلمات کلیدی
PFCRT-PCRERKTSTFSTBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Tail suspension test - آزمون تعلیق دمforced swim test - آزمون شناور اجباریResveratrol - رسوراترولbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استprefrontal cortex - قشر prefrontalbrain derived neurotrophic factor (BDNF) - مغز استخوان فاکتور نئوپروتئینی (BDNF)HPA - میلی بار یا هکتوپاسکالhypothalamic–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالreverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیExtracellular signal-regulated kinase (ERK) - کیناز تنظیم شده سیگنال خارج سلولی (ERK)
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has diverse biological activities. There is only limited information about the antidepressant-like effect of resveratrol. The present study assessed whether resveratrol treatment (20, 40 and 80Â mg/kg, i.p., 21Â days) has an antidepressant-like effect on the forced swim test (FST) and tail suspension test (TST) in mice and examined what its molecular targets might be. The results showed that resveratrol administration produced antidepressant-like effects in mice, evidenced by the reduced immobility time in the FST and TST, while it had no effect on the locomotor activity in the open field test. Resveratrol treatment significantly reduced serum corticosterone levels, which had been elevated by the FST and TST. Moreover, resveratrol increased brain-derived neurotrophic factor (BDNF) protein and extracellular signal-regulated kinase (ERK) phosphorylation levels in the prefrontal cortex and hippocampus. All of these antidepressant-like effects of resveratrol were essentially similar to those observed with the clinical antidepressant, fluoxetine. These results suggest that the antidepressant-like effects of resveratrol in the FST and TST are mediated, at least in part, by modulating hypothalamic-pituitary-adrenal axis, BDNF and ERK phosphorylation expression in the brain region of mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 112, 1 November 2013, Pages 104-110
Journal: Pharmacology Biochemistry and Behavior - Volume 112, 1 November 2013, Pages 104-110
نویسندگان
Zhen Wang, Jianhua Gu, Xueer Wang, Kai Xie, Qinsong Luan, Nianqing Wan, Qun Zhang, Hong Jiang, Dexiang Liu,