کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8351729 | 1541873 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adolescent binge-like ethanol exposure reduces basal α-MSH expression in the hypothalamus and the amygdala of adult rats
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کلمات کلیدی
AgRPBNSTα-MSHpro-opiomelanocortinVMHVTABEPMelanotan-IIPC1/3CRFPOMCDMHβ-MSHNACBECPNDMC-Rγ-MSHCeA - CEAImmunoreactivity - ایمنی فعالImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیpostnatal day - روز پس از زایمانMTII - سهcorticotropin releasing factor - عامل آزاد کننده کورتیکوتروپینblood ethanol concentration - غلظت اتانول خونArc - قوسPVN - مالیات بر ارزش افزودهhypothalamic–pituitary–adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالmelanocortin - ملانوکورتینAlcohol-preferring rats - موش های ترجیح دهنده الکلHPA - میلی بار یا هکتوپاسکالventral tegmental area - ناحیه تگمنتوم شکمیAdolescents - نوجوانیNucleus accumbens - هسته accumbensVentromedial nucleus of the hypothalamus - هسته Ventromedial هیپوتالاموسbed nucleus of the stria terminalis - هسته تخت ترمینال های استریhypothalamic arcuate nucleus - هسته قوس هیپوتالامیکcentral nucleus of amygdala - هسته مرکزی آمیگدالparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسdorsomedial nucleus of the hypothalamus - هسته ی dorsomedial هیپوتالاموسα-Melanocyte stimulating hormone - هورمون تحریک کننده α-ملانوستیlateral hypothalamus - هیپوتالاموس جانبیbody weight - وزن بدنagouti-related peptide - پپتید مرتبط با agouti
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Melanocortins (MC) are central peptides that have been implicated in the modulation of ethanol consumption. There is experimental evidence that chronic ethanol exposure reduces α-MSH expression in the limbic and hypothalamic brain regions and alters central pro-opiomelanocortin (POMC) mRNA activity in adult rats. Adolescence is a critical developmental period of high vulnerability in which ethanol exposure alters corticotropin releasing factor, neuropeptide Y, substance P and neurokinin neuropeptide activities, all of which have key roles in ethanol consumption. Given the involvement of MC and the endogenous inverse agonist AgRP in ethanol drinking, here we evaluate whether a binge-like pattern of ethanol treatment during adolescence has a relevant impact on basal and/or ethanol-stimulated α-MSH and AgRP activities during adulthood. To this end, adolescent Sprague-Dawley rats (beginning at PND25) were pre-treated with either saline (SP group) or binge-like ethanol exposure (BEP group; 3.0 g/kg given in intraperitoneal (i.p.) injections) of one injection per day over two consecutive days, followed by 2 days without injections, repeated for a total of 8 injections. Following 25 ethanol-free days, we evaluated α-MSH and AgRP immunoreactivity (IR) in the limbic and hypothalamic nuclei of adult rats (PND63) in response to ethanol (1.5 or 3.0 g/kg i.p.) and saline. We found that binge-like ethanol exposure during adolescence significantly reduced basal α-MSH IR in the central nucleus of the amygdala (CeA), the arcuate nucleus (Arc) and the paraventricular nucleus of the hypothalamus (PVN) during adulthood. Additionally, acute ethanol elicited AgRP IR in the Arc. Rats given the adolescent ethanol treatment required higher doses of ethanol than saline-treated rats to express AgRP. In light of previous evidence that endogenous MC and AgRP regulate ethanol intake through MC-receptor signaling, we speculate that the α-MSH and AgRP disturbances induced by binge-like ethanol exposure during adolescence may contribute to excessive ethanol consumption during adulthood.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 110, September 2013, Pages 66-74
Journal: Pharmacology Biochemistry and Behavior - Volume 110, September 2013, Pages 66-74
نویسندگان
Jose Manuel Lerma-Cabrera, Francisca Carvajal, Manuel Alcaraz-Iborra, Leticia de la Fuente, Montserrat Navarro, Todd E. Thiele, Inmaculada Cubero,