Hepcidin increases intracellular Ca2+ of osteoblast hFOB1.19 through L-type Ca2+ channels

► Hepcidin increases intracellular calcium of cultured hFOB1.19 cells. ► Increased intracellular Ca2+ with hepcidin incubation was blocked by nimodipine. ► The stimulatory effect of hepcidin on osteoblast intracellular Ca2+. ► The role of voltage-dependent L-type calcium channels in promoting the inward Ca2+ flow in this process.