Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2

► Signalling pathway of goldfish MCHRs is different from that of mammalian MCHRs. ► Compound 15 is a potent agonist of goldfish MCHR1 as well as mammalian MCHR1. ► Compound 30, a mammalian MCHR1 antagonist, is an agonist of goldfish MCHR1. ► This study will help to solve the molecular mechanism of the MCH system in goldfish.