کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8450734 | 1547687 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer EYA1 promotes tumor angiogenesis by activating the PI3K pathway in colorectal cancer](/preview/png/8450734.png)
چکیده انگلیسی
Blood vessels are one of the major routes for the dissemination of cancer cells. Malignant tumors release growth factors such as vascular endothelial growth factor(VEGF) to induce angiogenesis, thereby promoting metastasis. Here, we report that The Drosophila Eyes Absent Homologue 1 (EYA1), which is overexpressed in colorectal tumor cells, can promote colorectal tumor angiogenesis by coordinating with the hypoxia-inducible factor 1 (HIF-1α) to increase the expression of VEGF-A. Moreover, data indicated that the enhancement of HIF-1α expression by Eya1 depended on its ability to activate the phosphatidylinositol 3-kinase (PI3K) signaling pathways to increase the phosphorylation of AKT subunits. Overexpression of Eya1 increased tumor angiogenesis in vivo and in vitro. Our study suggested that Eya1 is essential in regulating cancer cell-mediated angiogenesis and contributes to tumor growth, and that Eya1 provides a potential and specific target for new anti-angiogenesis drug development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 367, Issue 1, 1 June 2018, Pages 37-46
Journal: Experimental Cell Research - Volume 367, Issue 1, 1 June 2018, Pages 37-46
نویسندگان
Shaoxin Cai, Xuefei Cheng, Yi Liu, Zhizun Lin, Wei Zeng, Changshun Yang, Lihang Liu, Ozor Anthony Chukwuebuka, Weihua Li,