کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8463815 | 1549401 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The plasticity of inflammatory monocyte responses to the inflamed central nervous system
ترجمه فارسی عنوان
پلاستیک پاسخ های مونوسیت التهابی به سیستم عصبی مرکزی ملتهب است
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کلمات کلیدی
CCLcMoPVirus encephalitisTNFC-C motif ligandDLNMDPIFN-α receptorWNVM-CSFIRFGM-CSFTLREAEHSCgranulocyte/macrophage colony stimulating factor - granulocyte / macrophage colony stimulating factorIFNAR - IFN؟Mϕ - Mφexperimental autoimmune encephalomyelitis - آنسفالومیلیت خودایمنی تجربیinterferon - اینترفرونIFN - اینترفرون هاToll-like receptor - تیالآرCNS - دستگاه عصبی مرکزیBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیDendritic cells - سلول های دندریتیکcentral nervous system - سیستم عصبی مرکزیinterferon regulatory factor - عامل تنظیمی اینترفرونtumour necrosis factor - عامل نکروز تومورmacrophage colony stimulating factor - فاکتور تحریک کننده کلون ماکروفاژMacrophage - ماکروفاژ Macrophages - ماکروفاژها،درشت خوارهاbone marrow - مغز استخوانMultiple sclerosis - مولتیپل اسکلروزیس(ام اس)Monocyte - مونوسیتMyeloid - میلوئیدCellular infiltration - نفوذ سلولیWest Nile virus - ویروس نیل غربیPlasticity - پلاستیکDraining lymph node - گره لنفاوی تخلیهLymph node - گره های لنفاوی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Over the last three decades it has become increasingly clear that monocytes, originally thought to have fixed, stereotypic responses to foreign stimuli, mediate exquisitely balanced protective and pathogenic roles in disease and immunity. This balance is crucial in core functional organs, such as the central nervous system (CNS), where minor changes in neuronal microenvironments and the production of immune factors can result in significant disease with fatal consequences or permanent neurological sequelae. Viral encephalitis and multiple sclerosis are examples of important human diseases in which the pathogenic contribution of monocytes recruited from the bone marrow plays a critical role in the clinical expression of disease, as they differentiate into macrophage or dendritic cells in the CNS to carry out effector functions. While antigen-specific lymphocyte populations are central to the adaptive immune response in both cases, in viral encephalitis a prominent macrophage infiltration may mediate immunopathological damage, seizure induction, and death. However, the autoimmune response to non-replicating, non-infectious, but abundant, self antigen has a different disease progression, associated with differentiation of significant numbers of infiltrating monocytes into dendritic cells in the CNS. Whilst a predominant presence of macrophages or dendritic cells in the inflamed CNS in viral encephalitis or multiple sclerosis is well described, the way in which the inflamed CNS mobilizes monocytes in the bone marrow to migrate to the CNS and the key drivers that lead to these specific differentiation pathways in vivo are not well understood. Here we review the current understanding of factors facilitating inflammatory monocyte generation, migration and entry into the brain, as well as their differentiation towards macrophages or dendritic cells in viral and autoimmune disease in relation to their respective disease outcomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 291, Issues 1â2, SeptemberâOctober 2014, Pages 49-57
Journal: Cellular Immunology - Volume 291, Issues 1â2, SeptemberâOctober 2014, Pages 49-57
نویسندگان
Thomas Myles Ashhurst, Caryn van Vreden, Paula Niewold, Nicholas Jonathan Cole King,