کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8474565 | 1550428 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats
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کلمات کلیدی
DMNQROS scavengerRCILVSPLVEDPLVDPrPPPTPdP/dtmax - dP / dtmaxROS - ROSmitochondrial ROS - ROS میتوکندریPermeability transition pore - افت فشار نفوذ پذیریimm - انحصارischemia/reperfusion - ایسکمی / رپرفیوژنischemia–reperfusion - ایسکمی-رپرفیوژنLeft ventricular developed pressure - بطن چپ توسعه یافته فشارinner mitochondrial membrane - درونی غشای میتوکندریelectron transport chain - زنجیره انتقال الکترونAging - سالخوردگیrate-pressure product - سرعت فشار محصولRespiratory control index - شاخص کنترل تنفسیHeart rate - ضربان قلبleft ventricular systolic pressure - فشار سیستولیک بطن چپleft ventricular end diastolic pressure - فشار پایین دیاستولیک بطن چپHeart - قلب lactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Mitochondria - میتوکندریاETc - و غیرهbody weight - وزن بدنHeart weight - وزن قلبReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats](/preview/png/8474565.png)
چکیده انگلیسی
Mitochondria-generated reactive oxygen species (ROS) play a crucial role in the pathogenesis of aging and age-associated diseases. In this study, we evaluated the effects of XJB-5-131 (XJB), a mitochondria-targeted ROS and electron scavenger, on cardiac resistance to ischemia-reperfusion (IR)-induced oxidative stress in aged rats. Male adult (5-month old, n = 17) and aged (29-month old, n = 19) Fischer Brown Norway (F344/BN) rats were randomly assigned to the following groups: adult (A), adult + XJB (AX), aged (O), and aged + XJB (OX). XJB was administered 3 times per week (3 mg/kg body weight, IP) for four weeks. At the end of the treatment period, cardiac function was continuously monitored in excised hearts using the Langendorff technique for 30 min, followed by 20 min of global ischemia, and 60-min reperfusion. XJB improved post-ischemic recovery of aged hearts, as evidenced by greater left ventricular developed-pressures and rate-pressure products than the untreated, aged-matched group. The state 3 respiration rates at complexes I, II and IV of mitochondria isolated from XJB-treated aged hearts were 57% (P < 0.05), 25% (P < 0.05) and 28% (P < 0.05), respectively, higher than controls. Ca2 +-induced swelling, an indicator of permeability transition pore opening, was reduced in the mitochondria of XJB-treated aged rats. In addition, XJB significantly attenuated the H2O2-induced depolarization of the mitochondrial inner membrane as well as the total and mitochondrial ROS levels in cultured cardiomyocytes. This study underlines the importance of mitochondrial ROS in aging-induced cardiac dysfunction and suggests that targeting mitochondrial ROS may be an effective therapeutic approach to protect the aged heart against IR injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 77, December 2014, Pages 136-146
Journal: Journal of Molecular and Cellular Cardiology - Volume 77, December 2014, Pages 136-146
نویسندگان
Nelson Escobales, Rebeca E. Nuñez, Sehwan Jang, Rebecca Parodi-Rullan, Sylvette Ayala-Peña, Joshua R. Sacher, Erin M. Skoda, Peter Wipf, Walter Frontera, Sabzali Javadov,