کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8482411 | 1551523 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vivo ameliorative effects of methanol leaf extract of Lawsonia inermis Linn on experimental Trypanosoma congolense infection in Wistar rats
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کلمات کلیدی
MDAAntitrypanosomalPSSkDNATBATCAEOFAntioxidant - آنتی اکسیدانtrichloroacetic acid - اسید ترشکلراکتیکThiobarbituric acid - اسید تیوباربیتوریکUnited States - ایالات متحده آمریکاanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTrypanosoma - تریپانوزوما، مته تنPacked cell volume - حجم سلول بسته بندی شدهstandard error of mean - خطای استاندارد میانگینintraperitoneal - داخل صفاقیErythrocyte osmotic fragility - شکنندگی اسمتیک اریتروسیتPhytochemistry - فیتوشیمی، شیمی گیاهmalondialdehyde - مالون دی آلدهیدSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیPCV یا Pneumococcal conjugate vaccine - واکسن کونژوگه پنوموکوک
موضوعات مرتبط
علوم پزشکی و سلامت
علوم و ابزار دامپزشکی
دامپزشکی
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چکیده انگلیسی
The aim of this study was to investigate the ameliorative effect of Lawsonia inermis Linn used traditionally against trypanosomosis. Twenty-five adult Wistar rats of both sex were individually infected intraperitoneally (IP) with 106Trypanosoma congolense per ml of blood. Following establishment of infection, the rats were randomly divided into five groups of 5 rats each. Rats in groups I, II, and III were treated with 125, 250 and 500Â mg/kg of the extract, respectively, while rats in groups IV and V were treated with 3.5Â mg/kg and 2Â ml/kg of diminazene aceturate (DM) once and physiological buffered saline, respectively. All treatments except DM were given orally for 7Â days IP. The antitrypanosomal effect of the plant was assessed by observing the level of parasitaemia daily, packed cell volume (PCV) weekly, erythrocyte osmotic fragility (EOF) and malondialdehyde (MDA) concentration on day 21. Phytochemical screening of the extract revealed the presence of alkaloids, carbohydrates, triterpenes, steroids, cardiac glycosides, saponins, tannins and flavonoids. The extract significantly (PÂ <Â 0.05) reduced levels of parasitaemia at 250Â mg/kg. PCV was higher (PÂ >Â 0.05) in extract treated groups but significantly higher (PÂ <Â 0.05) in group II at week 2 when compared to group V. Rats in group II had significantly lower values of EOF and MDA when compared with groups IV and V. Thus, the leaf of L. inermis has in addition to an antitrypanosomal effect against T. congolense in rats, an attenuating effect on the trypanosomosis pathology probably mediated via protection of the erythrocyte membrane against trypanosome-induced oxidative damage to the erythrocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Veterinary Science and Medicine - Volume 4, Issue 2, December 2016, Pages 33-40
Journal: International Journal of Veterinary Science and Medicine - Volume 4, Issue 2, December 2016, Pages 33-40
نویسندگان
Abdullah Mohammad Tauheed, Salisu Hashim Shittu, Mohammed Musa Suleiman, Buhari Habibu, Mohammed Umar Kawu, Patricia Ishaku Kobo, Peter Ofemile Yusuf,