کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8486340 1551767 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Designing an immunocyte-targeting delivery system by use of beta-glucan
ترجمه فارسی عنوان
طراحی سیستم تحویل هدفمند ایمونوسیت با استفاده از بتا گلوکان
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
A β-1,3-d-glucan called Schizophyllan (SPG) can form a novel complex with homo oligodeoxynucleotides (ODNs) via the combination of hydrogen bonding and hydrophobic interactions. Dectin-1 is a major receptor involved in the recognition of β-1,3-d-glucans and expressed on antigen presenting cells (APCs) including macrophages, dendritic cells, monocytes, neutrophils, and a subset of T cells. Therefore, the SPG/ODN complex can be used as APCs cell-specific delivery of functional ODNs including unmethylated CpG sequences (CpG-ODNs). In fact, CpG-ODN/SPG complex induced high antibody titers when it was administered to cynomolgus monkeys as adjutant of influenza vaccine. These results indicate that SPG can be an excellent immunocyte-targeting drug delivery system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 36, Issue 1, 2 January 2018, Pages 186-189
نویسندگان
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