Conservation of HIV-1 T cell epitopes across time and clades: Validation of immunogenic HLA-A2 epitopes selected for the GAIA HIV vaccine

► HIV-1 HLA-A2T cell epitopes selected based on conservation and immunogenicity. ► The balanced immunoinformatics approach produced 38 HLA-A2T cell epitopes for HIV-1. ► HIV-1 HLA-A2T cell epitopes were validated across time, clades and geography. ► T cell epitopes for inclusion in a globally relevant GAIA HIV vaccine.