کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8490945 | 1552345 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioavailability of di-peptide dl-methionyl-dl-methionine in comparison to dl-methionine in weaned and growing pigs
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
The relative bioavailability (RBV) of a dipeptide dl-methionyl-dl-methionine (dl-Met-Met) was compared with dl-methionine (dl-Met) in growing pigs (experiment 1; N-balance study) and in weaned pigs (experiment 2; performance study). In experiment 1, 42 barrows with an initial body weight (BW) of 21.0â¯Â±â¯1.37â¯kg were assigned to 7 dietary treatments with 6 replicate/pigs per treatment in a nitrogen (N) balance study to evaluate the RBV of dl-Met-Met to dl-Met. A basal diet (BD) was formulated to be adequate for all amino acids with the exception of Metâ¯+â¯Cys which was 68% of the requirement [4.7â¯g/kg standardized ileal digestible (SID) Metâ¯+â¯Cys; 11.5â¯g/kg SID Lys] for 20-25â¯kg pigs. Three graded levels of dl-Met (0.3, 0.6 and 0.9â¯g/kg) and dl-Met-Met (0.306, 0.612 and 0.919â¯g/kg) were supplemented to the BD to create diets 2-7. In experiment 2, a total of 189 weaned pigs (initial BW of 10.2â¯Â±â¯0.98â¯kg) were assigned to 7 dietary treatments with 9 replicates/pens of 3 pigs per treatment. The dietary treatments consisted of a Met-deficient BD (5.3â¯g/kg SID Metâ¯+â¯Cys; 13.0â¯g/kg SID Lys) and the same 3â¯graded levels of dl-Met and dl-Met-Met as in Exp. 1. In experiment 1, supplementation with dl-Met or dl-Met-Met linearly decreased (Pâ¯â¤â¯0.01; linear) urinary N excretion and increased (Pâ¯â¤â¯0.02; linear) N retained (g/day), N retention (% of intake and % of absorbed). However, there was no effect of Met sources on all N balance parameters. Based on the slope-ratio regression the RBV for dl-Met-Met compared to dl-Met was estimated 111% [95% confidence interval (CI): 63-158%] for N retained (g/d), 109% (95% CI: 57-160%) for N retention (% of intake) and 98% (95% CI: 43-154%) for N retention (% of absorbed) on an equi-molar basis. In experiment 2, the overall average daily gain (ADG) and gain:feed ratio (G:F) increased linearly (Pâ¯<â¯0.01) by supplementation with dl-Met or dl-Met-Met. The average daily feed intake increased by supplementation with dl-Met (Pâ¯=â¯0.02) and dl-Met-Met (Pâ¯=â¯0.09). For ADG, the RBV for dl-Met-Met was estimated 104% (95% CI: 66-141%) on an equi-molar basis by the slope-ratio. Based on G:F, the RBV for dl-Met-Met was estimated 117% (95% CI: 61-174%) on an equi-molar basis. The results of both experiments indicate that the bioavailability dl-Met-Met is not different and at least equally bioavailable as dl-Met as a Met source for pigs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Animal Feed Science and Technology - Volume 241, July 2018, Pages 94-101
Journal: Animal Feed Science and Technology - Volume 241, July 2018, Pages 94-101
نویسندگان
L.S. Santos, J.K. Htoo, C. Fracaroli, W.C. Silva, J.P. Gobi, A.M. Veira, N.A.A. Barbosa, L. Hauschild,