Poly(ADP-ribose) polymerase plays a differential role in DNA damage-response and cell death pathways in Trypanosoma cruzi

► Trypanosoma cruzi poly(ADP-ribose) polymerase (PARP) translocates to the nucleus in response to DNA damage. ► PAR metabolism is involved in at least two DNA strand break signalling pathways. ► PARP is connected with different cell death programs. ► Different DNA damaging agents induce distinct patterns of PARylated proteins.