کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8503982 | 1554293 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Absorption of bicarbonate in sheep omasum
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Transport of bicarbonate across the isolated epithelium of sheep omasum was studied in vitro in Ussing chambers in combination with the pH-Stat method. The transport of HCO3- occurred in both directions, but Jms HCO3- was significant larger than Jsm. Reducing the activity of the apical Na/H exchanger by a low mucosal Na concentration caused a significant reduction of Jms HCO3â. Mucosal amiloride or short chain fatty acids (25â¯mmolâ¯lâ1 SCFA) numerically decreased Jms HCO3â, but their combination (amilorideâ¯+â¯SCFA) caused a significant reduction, which was also observed after addition of the carboanhydrase inhibitor ethoxyzolamide. Concentrations of 5 or 15â¯mmol·lâ1 mucosal ammonia did not change transport rates. The obtained results indicate the importance of an undisturbed cytosolic pH for transcellular HCO3- transport, which is probably mediated by an anion exchanger in both the apical and basolateral membranes. Possible impairment of HCO3- transport appears to be an overlooked factor in the pathogenesis of displacement of the abomasum.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 118, June 2018, Pages 324-330
Journal: Research in Veterinary Science - Volume 118, June 2018, Pages 324-330
نویسندگان
Driton Caushi, Holger Martens,