C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities

Eight new C19-diterpenoid alkaloid arabinosides, named aconicarmichosides E−L (1−8), were isolated and characterized from an aqueous extract of the lateral roots of Aconitum carmichaelii (Fu Zi). These compounds, together with the previously reported four neoline 14-O-arabinosides from the same extract, represent the only examples of glycosidic diterpenoid alkaloids from nature. At a dose of 1.0 mg/kg (i.p.), compounds 1, 2, and 4-6 exhibited analgesic effects against acetic acid-induced writhing of mice.320