1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation

Obesity is associated with multiple adverse health outcomes collectively summarized as the “metabolic syndrome”, consisting of insulin resistance and dyslipidemia. Administration of 1,25(OH)2D3 protects MSG obese rats from the development of obesity and its related metabolic risks via increasing the infiltration of CD4+CD25+ regulatory T-cells in primary insulin targeted-tissues.494