کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8513770 1556499 2017 37 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Computational Modeling of Polymeric Physicochemical Properties for Formulation Development of a Drug Containing Basic Functionality
ترجمه فارسی عنوان
مدلسازی محاسباتی خواص فیزیکوشیمیایی پلیمری برای تولید فرمولاسیون یک داروی حاوی عملکرد اساسی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
In the present research, predictive models were developed by correlating polymeric properties with characteristics of a formulation containing a drug with basic heterocycle (glipizide). Glipizide tablets containing different polymers from 3 categories (immediate, moderate, and extended release) were prepared and evaluated. Dissolution kinetics indicated Korsmeyer-Peppas as the best-fit model, whereas transportability was influenced by release rate and hydrophobicity of the drug. Calculated polymeric descriptors were correlated with formulation properties for the development of predictive quantitative structure-property relationship models. Regression coefficients and subsequent validation of developed models indicated potential predictability of the model for formulation properties containing any drug with basic heterocycle. Such models could also help to decide the formulation composition for desired characteristics with saving of time and formulation cost.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 11, November 2017, Pages 3337-3345
نویسندگان
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