کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513840 | 1556501 | 2017 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical Implications Associated With the Posttranslational Modification-Induced Functional Impairment of Albumin in Oxidative Stress-Related Diseases
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کلمات کلیدی
HSACysteine-34Albumin - آلبومینischemia-modified albumin - آلبومین اصلاح شده ایسکمیhuman serum albumin - آلبومین سرم انسانیBranched-chain amino acid - آمینو اسید زنجیره ایposttranslational modification - اصلاح posttranslationalIma - ایماBCAA - بی سی ای ایkidney disease - بیماری کلیویLiver disease - بیماریهای کبدیBiomarker - بیومارکرOxidative stress - تنش اکسیداتیوDiabetes mellitus - دیابت قندیLigand binding - لیگاند اتصال
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recent research findings indicate that the posttranslational modification of human serum albumin (HSA) such as oxidation, glycation, truncation, dimerization, and carbamylation is related to certain types of diseases. We report herein on a simple and rapid analytical method, using an electrospray ionization time-of-flight mass spectrometry technique, that allows posttranslational modifications of HSA to be quantitatively and qualitatively evaluated with a high degree of sensitivity. In patients with chronic liver disease, chronic renal disease, and diabetes mellitus, an increase in the level of oxidized cysteine-34 (Cys-34) of HSA accompanied by a decrease in the level of reduced Cys-34 was observed. The redox status of Cys-34 was correlated with ligand binding and the antioxidative functions of HSA. Available evidence indicates that monitoring the redox state of Cys-34 not only could be a useful marker for evaluating the progression of disease and its complications but also would permit therapeutic efficacy to be predicted. The redox state of Cys-34 was also used as an index of the quality of HSA preparations. These data suggest that monitoring the posttranslational modifications of HSA can be important, because the function of HSA is related not only to its serum concentration but also to the preservation of its structural integrity under disease conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 9, September 2017, Pages 2195-2203
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 9, September 2017, Pages 2195-2203
نویسندگان
Hiroshi Watanabe, Tadashi Imafuku, Masaki Otagiri, Toru Maruyama,