کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8513863 1556501 2017 25 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transporters Involved in Metformin Pharmacokinetics and Treatment Response
ترجمه فارسی عنوان
متخصصان حمل و نقل در متخصصین دارو و واکنش درمانی متفورمین شرکت می کنند
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
Metformin, widely used as first-line treatment for type 2 diabetes, exists primarily as a hydrophilic cation at physiological pHs. As such, membrane transporters play a substantial role in its absorption, tissues distribution, and renal elimination. Multiple organic cation transporters are determinants of the pharmacokinetics of metformin, and many of them are important in its pharmacological action, as mediators of metformin entry into target tissues. Furthermore, a recent genome-wide association study in a large multi-ethnic population implicated polymorphisms in SLC2A2, encoding the glucose transporter, GLUT2, as important determinants of response to metformin. Here, we describe the key transporters associated with metformin pharmacokinetics and response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 9, September 2017, Pages 2245-2250
نویسندگان
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