کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513971 | 1556502 | 2017 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel Superparamagnetic Microdevices Based on Magnetized PLGA/PLA Microparticles Obtained by Supercritical Fluid Emulsion and Coating by Carboxybetaine-Functionalized Chitosan Allowing the Tuneable Release of Therapeutics
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Microcarriers showed a mean size of 800 ± 60 nm with an encapsulation efficiency of up to 90%. The inversion of surface charge, after the f-chi coating, suggested the presence of a uniform functionalized surface available for further chemical linkage. The external chitosan layer had a thickness of 200 ± 50 nm. An excellent MAG dispersion was confirmed within the biopolymer matrix that was shown to be responsive to external magnetic field; indeed, Fluo was released over 3 or 5 days from PLGA or f-chi-PLGA microdevices into phosphate-buffered saline medium at 37°C, whereas remote on-off controlled release was achieved when an alternating magnetic field was applied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 8, August 2017, Pages 2097-2105
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 8, August 2017, Pages 2097-2105
نویسندگان
Vincenzo Cricchio, Mark Best, Ernesto Reverchon, Nicola Maffulli, Gary Phillips, Matteo Santin, Giovanna Della Porta,