کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514875 | 1556512 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Effective Solubilization of Hydrophobic Drugs Using Epigallocatechin Gallate or Tannic Acid-Based Formulations
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کلمات کلیدی
DTXDENAMDCKPTXEGCGHBSSHUVECSolubility - انحلال پذیریepigallocatechin gallate - اپی گالوستاچین گالاتBiomaterials - بیومتریال، بیومواد Macromolecular drug delivery - تحویل داروی مقوی مولکولیControlled delivery - تحویل کنترل شدهDocetaxel - داکتاکسلHuman umbilical vein endothelial cells - سلول های اندوتلیالی ورید ناف انسانMadin-Darby canine kidney cells - سلول های کلیوی کانین Madin-DarbyNatural products - فرآورده های طبیعیMHC - مجموعه سازگاری بافتی اصلیPaclitaxel - پاکلی تاکسل
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The Effective Solubilization of Hydrophobic Drugs Using Epigallocatechin Gallate or Tannic Acid-Based Formulations The Effective Solubilization of Hydrophobic Drugs Using Epigallocatechin Gallate or Tannic Acid-Based Formulations](/preview/png/8514875.png)
چکیده انگلیسی
Hydrotropic solubilization of hydrophobic drugs requires supramolar amounts of hydrotropes with potential toxicity issues. We investigated the use of epigallocatechin gallate (EGCG) and tannic acid at millimolar concentrations, as hydrotrope-like solubilizing agents. Paclitaxel, docetaxel, amphotherecin B, curcumin, or rapamycin were dried down with EGCG or tannic acid from ethanol and then redissolved in aqueous media. Following centrifugation and filtration, the drug solubility was measured using HPLC. The uptake of docetaxel into cells from EGCG-based solutions was measured using radiolabeled drugs. Both EGCG and tannic acid effectively increased the aqueous solubility of all drugs from low levels (μg/mL) to high levels (mg/mL) in a concentration-dependent fashion at millimolar concentrations. Solutions were generally stable at room temperature over 24 h. Compared with micellar formulations, EGCG-based solutions of docetaxel demonstrated markedly improved drug uptake or transport levels in all cell lines. The use of these additives may provide improved formulation of various hydrophobic drugs using oral, parenteral, localized, or device-associated delivery systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 10, October 2016, Pages 3143-3152
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 10, October 2016, Pages 3143-3152
نویسندگان
John K. Jackson, Kevin Letchford,