Role of clove oil in solvent exchange-induced doxycycline hyclate-loaded Eudragit RS in situ forming gel

Doxycycline hyclate (DH) loaded Eudragit RS (ERS) ISG comprising clove oil (CO) could transform into matrix depot after exposure to the simulated crevicular fluid, minimize DH burst release with sustainable manner and inhibit against S. aureus, E. coli, S. mutans and P. gingivalis which this activity depended on the ratio of CO and N-methyl pyrrolidone (NMP).