کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8518992 1556728 2018 23 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
LAL test and RPT for endotoxin detection of CPT-11/DSPE-mPEG2000 nanoformulation: What if traditional methods are not applicable?
چکیده انگلیسی
Endotoxin can be measured mainly by two methods: the Rabbit Pyrogen Test (RPT) and Limulus Amebocyte Lysate (LAL) assay. We found that a chemotherapeutic drug nanoformulation composed of irinotecan hydrochloride and an amphiphilic molecule DSPE-mPEG2000 can interfere with the LAL. Furthermore, the RPT results indicated that at a relatively high dosage, the drug irinotecan hydrochloride can induce a hypothermia effect which forces us to reduce the dose. So it is necessary to develop new methods for the detection of endotoxin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 13, Issue 3, May 2018, Pages 289-296
نویسندگان
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