کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8522321 1557752 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phytochemical contents and biological evaluation of Ruta chalepennsis L. growing in Saudi Arabia
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Phytochemical contents and biological evaluation of Ruta chalepennsis L. growing in Saudi Arabia
چکیده انگلیسی
Phytochemical screening of Ruta chalepensis L. exhibited the presence of different chemical groups. The dried aerial parts of the plant was total extracted by ethanol and successively using chloroform, ethyl acetate and Butanol, out of the successive extracts four compounds namely, scopletin, kaempferol, quercetin, quercetin 3-O-α-L-rhamno glucopyranosyl (Rutin) were isolated and biological evaluations. Total ethanol and successive extracts; chloroform, ethyl acetate and Butanol were produced excellent antimicrobial activities against gram negative bacteria, gram positive bacteria and fungi. Ethyl acetate extract was the best for inhibition of the microorganism's growth. All extracts (total ethanol, and successive extracts) showed DPPH radical scavenging activity in a concentration-dependent manner. The best antioxidant activity was obtained by ethyl acetate & n-butanol extract (94.28%, IC50 = 56.6 µg/ml). Also All extracts (total ethanol, and successive extracts) showed anticoagulant activity at higher concentration with prolonged clotting time 6:30 and 4:30 s at 10 mg/ml concentrations, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Pharmaceutical Journal - Volume 26, Issue 4, May 2018, Pages 504-508
نویسندگان
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