کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8522340 | 1557752 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The possible mechanisms of protocatechuic acid-induced central analgesia
ترجمه فارسی عنوان
مکانیسم های احتمالی آنتی بادی مرکزی ناشی از اسید پروتکتاتوچوئیک
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
چکیده انگلیسی
It is aimed to investigate the central antinociceptive effect of protocatechuic acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C, α2-adrenergic and muscarinic receptors in protocatechuic acid-induced central analgesia in mice. Time-dependent antinociceptive effects of protocatechuic acid at the oral doses of 75, 150 and 300â¯mg/kg were tested in hot-plate (integrated supraspinal response) and tail-immersion (spinal reflex) tests in mice. To investigate the mechanisms of action; the mice administered 300â¯mg/kg protocatechuic acid (p.o.) were pre-treated with non-specific opioid antagonist naloxone (5â¯mg/kg, i.p.), serotonin 5-HT2A/2C receptor antagonist ketanserin (1â¯mg/kg, i.p.), α2-adrenoceptor antagonist yohimbine (1â¯mg/kg, i.p.) and non-specific muscarinic antagonist atropine (5â¯mg/kg, i.p.), respectively. The antinociceptive effect of protocatechuic acid was observed at the doses of 75, 150 and 300â¯mg/kg in tail-immersion test, at the doses of 150 and 300â¯mg/kg in hot-plate test at different time interval. The enhancement in the latency of protocatechuic acid-induced response to thermal stimuli was antagonized by yohimbine, naloxone and atropine in tail-immersion test, while it was antagonized only by yohimbine and naloxone pretreatments in hot-plate test. These results indicated that protocatechuic acid has the central antinociceptive action that is probably organized by spinal mediated cholinergic and opiodiergic, also spinal and supraspinal mediated noradrenergic modulation. However, further studies are required to understand how protocatechuic acid organizes the interactions of these modulatory systems. As a whole, these findings reinforce that protocatechuic acid is a potential agent that might be used for pain relief. Additionally, the clarification of the effect and mechanisms of action of protocatechuic acid will contribute to new therapeutic approaches and provide guidance for new drug development studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Pharmaceutical Journal - Volume 26, Issue 4, May 2018, Pages 541-545
Journal: Saudi Pharmaceutical Journal - Volume 26, Issue 4, May 2018, Pages 541-545
نویسندگان
Rana Arslan, Sule Aydin, Dilara Nemutlu Samur, Nurcan Bektas,