کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8523071 | 1557787 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters](/preview/png/8523071.png)
چکیده انگلیسی
Rift Valley fever virus (RVFV) is a mosquito-borne pathogen endemic to sub-Saharan Africa and the Arabian Peninsula. There are no approved antiviral therapies or vaccines available to treat or prevent severe disease associated with RVFV infection in humans. The adenosine analog, galidesivir (BCX4430), is a broad-spectrum antiviral drug candidate with in vitro antiviral potency (EC50 of less than 50â¯Î¼M) in more than 20 different viruses across eight different virus families. Here we report on the activity of galidesivir in the hamster model of peracute RVFV infection. Intramuscular and intraperitoneal treatments effectively limited systemic RVFV (strain ZH501) infection as demonstrated by significantly improved survival outcomes and the absence of infectious virus in the spleen and the majority of the serum, brain, and liver samples collected from infected animals. Our findings support the further development of galidesivir as an antiviral therapy for use in treating severe RVFV infection, and possibly other related phleboviral diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 156, August 2018, Pages 38-45
Journal: Antiviral Research - Volume 156, August 2018, Pages 38-45
نویسندگان
Jonna B. Westover, Amanda Mathis, Ray Taylor, Luci Wandersee, Kevin W. Bailey, Eric J. Sefing, Brady T. Hickerson, Kie-Hoon Jung, William P. Sheridan, Brian B. Gowen,