کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8523267 | 1557790 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Susceptibility of paramyxoviruses and filoviruses to inhibition by 2â²-monofluoro- and 2â²-difluoro-4â²-azidocytidine analogs
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Susceptibility of paramyxoviruses and filoviruses to inhibition by 2â²-monofluoro- and 2â²-difluoro-4â²-azidocytidine analogs Susceptibility of paramyxoviruses and filoviruses to inhibition by 2â²-monofluoro- and 2â²-difluoro-4â²-azidocytidine analogs](/preview/png/8523267.png)
چکیده انگلیسی
Ebolaviruses, marburgviruses, and henipaviruses are zoonotic pathogens belonging to the Filoviridae and Paramyxoviridae families. They exemplify viruses that continue to spill over into the human population, causing outbreaks characterized by high mortality and significant clinical sequelae in survivors of infection. There are currently no approved small molecule therapeutics for use in humans against these viruses. In this study, we evaluated the antiviral activity of the nucleoside analog 4â²-azidocytidine (4â²N3-C, R1479) and its 2â²-monofluoro- and 2â²-difluoro-modified analogs (2â²F-4â²N3-C and 2â²diF-4â²N3-C) against representative paramyxoviruses (Nipah virus, Hendra virus, measles virus, and human parainfluenza virus 3) and filoviruses (Ebola virus, Sudan virus, and Ravn virus). We observed enhanced antiviral activity against paramyxoviruses with both 2â²diF-4â²N3-C and 2â²F-4â²N3-C compared to R1479. On the other hand, while R1479 and 2â²diF-4â²N3-C inhibited filoviruses similarly to paramyxoviruses, we observed 10-fold lower filovirus inhibition by 2â²F-4â²N3-C. To our knowledge, this is the first study to compare the susceptibility of paramyxoviruses and filoviruses to R1479 and its 2â²-fluoro-modified analogs. The activity of these compounds against negative-strand RNA viruses endorses the development of 4â²-modified nucleoside analogs as broad-spectrum therapeutics against zoonotic viruses of public health importance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 153, May 2018, Pages 101-113
Journal: Antiviral Research - Volume 153, May 2018, Pages 101-113
نویسندگان
Michael K. Lo, Paul C. Jordan, Sarah Stevens, Yuen Tam, Jerome Deval, Stuart T. Nichol, Christina F. Spiropoulou,